Since the occupation of the Amazon region, with the exploitation of its hydroelectric and mining potential, the expansion of the agricultural frontier and the road network, colonization projects and various migratory movements within and outside the region have been observed. As a result, there was an accelerated expansion of several cities, which are characterized by low levels of basic services and infrastructure, with low qualification of the workforce and entrepreneurship. The lack of similar experiences has led to unappropriated models of land use and occupation in these cities, which are inadequate for the region's reality. The need for a differentiated and sustainable development model in the region has become evident. The lack of successful models has caused a lack of investment in modern, dynamic and high-value economic activities, as well as in social infrastructure. This factor generated a circle configured by the absence of good projects and the replicability of success cases, largely due to the lack of information, dissemination and exchange of local experiences. Successful experiences have no traction and do not multiply. In a context of imminent threats to policies to reduce deforestation and the spread of extensive fires in the region, responses arise from the perspective of cooperation that need support to be developed with quality. To this end, ICLEI South America and the International Institute for Sustainability join the initiative of the Konrad Adenauer Foundation, within the scope of the Regional Program for Energy Security and Climate Change in Latin America, to establish the Forum of Pan-Amazonian Cities.