In order to meet the climate change mitigation objectives of the EU and the objectives of the Paris Agreement, it’s inevitable that the EU phases out fossil fuel consumption in the power sector and decarbonizes fossil-fuel dependent industries. Decarbonization will lead to deep structural changes with implications for regional economies, labour markets, and for the regions’ social, political, cultural and demographic composition. If not managed well, these structural changes may cause serious economic impacts, societal upheaval, aggravated social inequalities and hardship. To minimize such consequences it’s necessary to better understand the patterns and dynamics of structural change in response to decarbonization at the regional level, to understand which parameters determine the pace of transformation as well as the capacity of regional actors to adapt and pro-actively create alternative structures. This project aims to enable these activities through highly integrated, inter- and transdisciplinary research working in close collaboration with regional stakeholders. It combines quantitative model-based research with qualitative in-depth analysis.